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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKM
All Species:
30
Human Site:
S255
Identified Species:
55
UniProt:
P08237
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08237
NP_000280.1
780
85183
S255
S
E
T
R
T
R
G
S
R
L
N
I
I
I
V
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
S326
S
E
T
R
T
R
G
S
R
L
N
I
I
I
V
Dog
Lupus familis
XP_544922
751
82459
I245
I
D
R
N
G
K
P
I
S
S
R
Y
V
K
D
Cat
Felis silvestris
Mouse
Mus musculus
P47857
780
85250
S255
S
E
T
R
T
R
G
S
R
L
N
I
I
I
V
Rat
Rattus norvegicus
P47858
780
85541
S255
S
E
T
R
T
R
G
S
R
L
N
I
I
I
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511162
864
94802
K335
S
E
N
R
A
R
K
K
R
L
N
I
I
I
V
Chicken
Gallus gallus
NP_989554
769
83907
S243
T
E
T
R
L
G
G
S
R
L
N
I
I
I
V
Frog
Xenopus laevis
NP_001086921
808
88294
S284
S
E
T
R
G
R
G
S
R
L
N
I
I
I
V
Zebra Danio
Brachydanio rerio
NP_001004575
784
85614
S257
T
E
T
R
N
A
G
S
R
L
N
V
I
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
Q257
A
Q
E
R
S
A
G
Q
R
L
N
I
V
I
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
K248
G
S
V
R
K
M
G
K
R
Q
N
V
I
I
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
K438
S
K
H
R
S
R
G
K
R
T
T
I
V
V
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.5
90.4
67.6
N.A.
97.8
96.6
N.A.
65.2
81.2
81.4
77.8
N.A.
58.7
N.A.
39.6
N.A.
Protein Similarity:
100
82.8
91.1
81.7
N.A.
99
98.2
N.A.
76.2
90.1
90.3
88.7
N.A.
75.7
N.A.
57.6
N.A.
P-Site Identity:
100
80
100
0
N.A.
100
100
N.A.
73.3
80
93.3
73.3
N.A.
53.3
N.A.
40
N.A.
P-Site Similarity:
100
93.3
100
20
N.A.
100
100
N.A.
73.3
86.6
93.3
86.6
N.A.
80
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
16
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
70
8
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
0
0
0
16
8
85
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
8
0
0
0
77
77
85
8
% I
% Lys:
0
8
0
0
8
8
8
24
0
0
0
0
0
8
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
77
0
0
0
0
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
8
0
0
0
0
0
85
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
8
0
8
0
0
0
0
0
% Q
% Arg:
0
0
8
93
0
62
0
0
93
0
8
0
0
0
0
% R
% Ser:
54
8
0
0
24
0
0
62
8
8
0
0
0
0
0
% S
% Thr:
16
0
62
0
31
0
0
0
0
8
8
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
16
24
8
77
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _